A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Abstract Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates. Thus, these approaches often have limitations that compro...

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Bibliographic Details
Main Authors: Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/6dfa7bddb1ad49129d7c2d0b60f32013
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