The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts

Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often accompanied by the occurrence of resistant mu...

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Autores principales: Ana Cristina Gonzalez-Perez, Markus Stempel, Emanuel Wyler, Christian Urban, Antonio Piras, Thomas Hennig, Sabina Ganskih, Yuanjie Wei, Albert Heim, Markus Landthaler, Andreas Pichlmair, Lars Dölken, Mathias Munschauer, Florian Erhard, Melanie M. Brinkmann
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Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://doaj.org/article/6e425387300544bf986a531f0f85f1a2
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spelling oai:doaj.org-article:6e425387300544bf986a531f0f85f1a22021-11-03T21:15:04Z The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts 2150-751110.1128/mBio.02683-20https://doaj.org/article/6e425387300544bf986a531f0f85f1a22021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02683-20https://doaj.org/toc/2150-7511 Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often accompanied by the occurrence of resistant mutants.Ana Cristina Gonzalez-PerezMarkus StempelEmanuel WylerChristian UrbanAntonio PirasThomas HennigSabina GanskihYuanjie WeiAlbert HeimMarkus LandthalerAndreas PichlmairLars DölkenMathias MunschauerFlorian ErhardMelanie M. BrinkmannAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
Ana Cristina Gonzalez-Perez
Markus Stempel
Emanuel Wyler
Christian Urban
Antonio Piras
Thomas Hennig
Sabina Ganskih
Yuanjie Wei
Albert Heim
Markus Landthaler
Andreas Pichlmair
Lars Dölken
Mathias Munschauer
Florian Erhard
Melanie M. Brinkmann
The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts
description Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often accompanied by the occurrence of resistant mutants.
format article
author Ana Cristina Gonzalez-Perez
Markus Stempel
Emanuel Wyler
Christian Urban
Antonio Piras
Thomas Hennig
Sabina Ganskih
Yuanjie Wei
Albert Heim
Markus Landthaler
Andreas Pichlmair
Lars Dölken
Mathias Munschauer
Florian Erhard
Melanie M. Brinkmann
author_facet Ana Cristina Gonzalez-Perez
Markus Stempel
Emanuel Wyler
Christian Urban
Antonio Piras
Thomas Hennig
Sabina Ganskih
Yuanjie Wei
Albert Heim
Markus Landthaler
Andreas Pichlmair
Lars Dölken
Mathias Munschauer
Florian Erhard
Melanie M. Brinkmann
author_sort Ana Cristina Gonzalez-Perez
title The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts
title_short The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts
title_full The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts
title_fullStr The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts
title_full_unstemmed The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral <i>UL4</i> / <i>UL5</i> Transcripts
title_sort zinc finger antiviral protein zap restricts human cytomegalovirus and selectively binds and destabilizes viral <i>ul4</i> / <i>ul5</i> transcripts
publisher American Society for Microbiology
publishDate 2021
url https://doaj.org/article/6e425387300544bf986a531f0f85f1a2
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