Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair

Altering cellular responses to double-strand breaks in DNA could rebalance CRISPRediting outcomes. Here, the authors use a pooled CRISPR screen to identify inhibition of CDC7 as a strategy to improve HDR outcomes.

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Auteurs principaux: Beeke Wienert, David N. Nguyen, Alexis Guenther, Sharon J. Feng, Melissa N. Locke, Stacia K. Wyman, Jiyung Shin, Katelynn R. Kazane, Georgia L. Gregory, Matthew A. M. Carter, Francis Wright, Bruce R. Conklin, Alex Marson, Chris D. Richardson, Jacob E. Corn
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/6ea294e461964f21b3fa07be064041d4
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Internet

https://doaj.org/article/6ea294e461964f21b3fa07be064041d4

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