IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

Innate lymphoid cells (ILCs) play critical immunological roles including immune surveillance at mucosal sites. Here the authors show that during nasal inflammation pathogen-induced cytokine production guides the differentiation of ILCs.

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Autores principales:	Korneliusz Golebski, Xavier R. Ros, Maho Nagasawa, Sophie van Tol, Balthasar A. Heesters, Hajar Aglmous, Chantal M. A. Kradolfer, Medya M. Shikhagaie, Sven Seys, P. W. Hellings, Cornelis M. van Drunen, Wytske J. Fokkens, Hergen Spits, Suzanne M. Bal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ea86cb26d194858951641d2dc4ea3bd
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spelling	oai:doaj.org-article:6ea86cb26d194858951641d2dc4ea3bd2021-12-02T15:35:36ZIL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation10.1038/s41467-019-09883-72041-1723https://doaj.org/article/6ea86cb26d194858951641d2dc4ea3bd2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09883-7https://doaj.org/toc/2041-1723Innate lymphoid cells (ILCs) play critical immunological roles including immune surveillance at mucosal sites. Here the authors show that during nasal inflammation pathogen-induced cytokine production guides the differentiation of ILCs.Korneliusz GolebskiXavier R. RosMaho NagasawaSophie van TolBalthasar A. HeestersHajar AglmousChantal M. A. KradolferMedya M. ShikhagaieSven SeysP. W. HellingsCornelis M. van DrunenWytske J. FokkensHergen SpitsSuzanne M. BalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Korneliusz Golebski Xavier R. Ros Maho Nagasawa Sophie van Tol Balthasar A. Heesters Hajar Aglmous Chantal M. A. Kradolfer Medya M. Shikhagaie Sven Seys P. W. Hellings Cornelis M. van Drunen Wytske J. Fokkens Hergen Spits Suzanne M. Bal IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
description	Innate lymphoid cells (ILCs) play critical immunological roles including immune surveillance at mucosal sites. Here the authors show that during nasal inflammation pathogen-induced cytokine production guides the differentiation of ILCs.
format	article
author	Korneliusz Golebski Xavier R. Ros Maho Nagasawa Sophie van Tol Balthasar A. Heesters Hajar Aglmous Chantal M. A. Kradolfer Medya M. Shikhagaie Sven Seys P. W. Hellings Cornelis M. van Drunen Wytske J. Fokkens Hergen Spits Suzanne M. Bal
author_facet	Korneliusz Golebski Xavier R. Ros Maho Nagasawa Sophie van Tol Balthasar A. Heesters Hajar Aglmous Chantal M. A. Kradolfer Medya M. Shikhagaie Sven Seys P. W. Hellings Cornelis M. van Drunen Wytske J. Fokkens Hergen Spits Suzanne M. Bal
author_sort	Korneliusz Golebski
title	IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
title_short	IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
title_full	IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
title_fullStr	IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
title_full_unstemmed	IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
title_sort	il-1β, il-23, and tgf-β drive plasticity of human ilc2s towards il-17-producing ilcs in nasal inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6ea86cb26d194858951641d2dc4ea3bd
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IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

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