P62 accumulates through neuroanatomical circuits in response to tauopathy propagation

Abstract In Alzheimer’s disease and related tauopathies, trans-synaptic transfer and accumulation of pathological tau from donor to recipient neurons is thought to contribute to disease progression, but the underlying mechanisms are poorly understood. Using complementary in vivo and in vitro models,...

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Autores principales: François-Xavier Blaudin de Thé, Benjamin Lassus, Ari W. Schaler, Stephanie L. Fowler, Chris N. Goulbourne, Ross Jeggo, Clotilde Mannoury la Cour, Mark J. Millan, Karen E. Duff
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
p62
Acceso en línea:https://doaj.org/article/6ec10d2a588a40fb82206e796520623e
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