An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing

An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing

Abstract Background Multi-sample comparison is commonly used in cancer genomics studies. By using next-generation sequencing (NGS), a mutation's status in a specific sample can be measured by the number of reads supporting mutant or wildtype alleles. When no mutant reads are detected, it could...

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Autores principales: Nicholas Hutson, Fenglin Zhan, James Graham, Mitsuko Murakami, Han Zhang, Sujana Ganaparti, Qiang Hu, Li Yan, Changxing Ma, Song Liu, Jun Xie, Lei Wei
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Negative status
Tumor heterogeneity
Liquid biopsy
Next-generation sequencing
Genetic testing
Personalized medicine
Internal medicine
RC31-1245
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/6ec5c0fa598645aab0521a3ef24101c0
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https://doaj.org/article/6ec5c0fa598645aab0521a3ef24101c0

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