An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing

Abstract Background Multi-sample comparison is commonly used in cancer genomics studies. By using next-generation sequencing (NGS), a mutation's status in a specific sample can be measured by the number of reads supporting mutant or wildtype alleles. When no mutant reads are detected, it could...

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Autores principales:	Nicholas Hutson, Fenglin Zhan, James Graham, Mitsuko Murakami, Han Zhang, Sujana Ganaparti, Qiang Hu, Li Yan, Changxing Ma, Song Liu, Jun Xie, Lei Wei
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Negative status Tumor heterogeneity Liquid biopsy Next-generation sequencing Genetic testing Personalized medicine Internal medicine RC31-1245 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/6ec5c0fa598645aab0521a3ef24101c0
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An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing

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