Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts

Little is known about the pathways that maintain mitochondrial structure and function under neuronal stress conditions. Here, authors demonstrate that the Mul1-Mfn2 pathway plays a checkpoint role in maintaining mitochondrial integrity and energy maintenance by ensuring ER-mitochondrial tethering an...

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Autores principales:	Rajat Puri, Xiu-Tang Cheng, Mei-Yao Lin, Ning Huang, Zu-Hang Sheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f1424b4200a43308728c4d36f509016
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spelling	oai:doaj.org-article:6f1424b4200a43308728c4d36f5090162021-12-02T15:36:20ZMul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts10.1038/s41467-019-11636-52041-1723https://doaj.org/article/6f1424b4200a43308728c4d36f5090162019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11636-5https://doaj.org/toc/2041-1723Little is known about the pathways that maintain mitochondrial structure and function under neuronal stress conditions. Here, authors demonstrate that the Mul1-Mfn2 pathway plays a checkpoint role in maintaining mitochondrial integrity and energy maintenance by ensuring ER-mitochondrial tethering and preventing mitophagy.Rajat PuriXiu-Tang ChengMei-Yao LinNing HuangZu-Hang ShengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajat Puri Xiu-Tang Cheng Mei-Yao Lin Ning Huang Zu-Hang Sheng Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
description	Little is known about the pathways that maintain mitochondrial structure and function under neuronal stress conditions. Here, authors demonstrate that the Mul1-Mfn2 pathway plays a checkpoint role in maintaining mitochondrial integrity and energy maintenance by ensuring ER-mitochondrial tethering and preventing mitophagy.
format	article
author	Rajat Puri Xiu-Tang Cheng Mei-Yao Lin Ning Huang Zu-Hang Sheng
author_facet	Rajat Puri Xiu-Tang Cheng Mei-Yao Lin Ning Huang Zu-Hang Sheng
author_sort	Rajat Puri
title	Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
title_short	Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
title_full	Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
title_fullStr	Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
title_full_unstemmed	Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
title_sort	mul1 restrains parkin-mediated mitophagy in mature neurons by maintaining er-mitochondrial contacts
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6f1424b4200a43308728c4d36f509016
work_keys_str_mv	AT rajatpuri mul1restrainsparkinmediatedmitophagyinmatureneuronsbymaintainingermitochondrialcontacts AT xiutangcheng mul1restrainsparkinmediatedmitophagyinmatureneuronsbymaintainingermitochondrialcontacts AT meiyaolin mul1restrainsparkinmediatedmitophagyinmatureneuronsbymaintainingermitochondrialcontacts AT ninghuang mul1restrainsparkinmediatedmitophagyinmatureneuronsbymaintainingermitochondrialcontacts AT zuhangsheng mul1restrainsparkinmediatedmitophagyinmatureneuronsbymaintainingermitochondrialcontacts
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Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts

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