Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis

The Strecker reaction is a power method for the synthesis of cyano-substituted compounds. Here the authors report a dual-reagent system for asymmetric Strecker reactions, where an in situformed organocatalyst/methyl acrylate zwitterionic adduct activates both the cyanide source and the electrophile.

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Autores principales: Hong-Yu Wang, Chang-Wu Zheng, Zhuo Chai, Jia-Xing Zhang, Gang Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6f18c64ef0bd4553bc9b8c7431accbb9
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