Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis

Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis

The Strecker reaction is a power method for the synthesis of cyano-substituted compounds. Here the authors report a dual-reagent system for asymmetric Strecker reactions, where an in situformed organocatalyst/methyl acrylate zwitterionic adduct activates both the cyanide source and the electrophile.

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Autores principales: Hong-Yu Wang, Chang-Wu Zheng, Zhuo Chai, Jia-Xing Zhang, Gang Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6f18c64ef0bd4553bc9b8c7431accbb9
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spelling oai:doaj.org-article:6f18c64ef0bd4553bc9b8c7431accbb92021-12-02T17:32:50ZAsymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis10.1038/ncomms127202041-1723https://doaj.org/article/6f18c64ef0bd4553bc9b8c7431accbb92016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12720https://doaj.org/toc/2041-1723The Strecker reaction is a power method for the synthesis of cyano-substituted compounds. Here the authors report a dual-reagent system for asymmetric Strecker reactions, where an in situformed organocatalyst/methyl acrylate zwitterionic adduct activates both the cyanide source and the electrophile.Hong-Yu WangChang-Wu ZhengZhuo ChaiJia-Xing ZhangGang ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hong-Yu Wang
Chang-Wu Zheng
Zhuo Chai
Jia-Xing Zhang
Gang Zhao
Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
description The Strecker reaction is a power method for the synthesis of cyano-substituted compounds. Here the authors report a dual-reagent system for asymmetric Strecker reactions, where an in situformed organocatalyst/methyl acrylate zwitterionic adduct activates both the cyanide source and the electrophile.
format article
author Hong-Yu Wang
Chang-Wu Zheng
Zhuo Chai
Jia-Xing Zhang
Gang Zhao
author_facet Hong-Yu Wang
Chang-Wu Zheng
Zhuo Chai
Jia-Xing Zhang
Gang Zhao
author_sort Hong-Yu Wang
title Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
title_short Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
title_full Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
title_fullStr Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
title_full_unstemmed Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
title_sort asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6f18c64ef0bd4553bc9b8c7431accbb9
work_keys_str_mv AT hongyuwang asymmetriccyanationofiminesviadipeptidederivedorganophosphinedualreagentcatalysis
AT changwuzheng asymmetriccyanationofiminesviadipeptidederivedorganophosphinedualreagentcatalysis
AT zhuochai asymmetriccyanationofiminesviadipeptidederivedorganophosphinedualreagentcatalysis
AT jiaxingzhang asymmetriccyanationofiminesviadipeptidederivedorganophosphinedualreagentcatalysis
AT gangzhao asymmetriccyanationofiminesviadipeptidederivedorganophosphinedualreagentcatalysis
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