N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.

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Autores principales: Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/6f2f436288994d16853156c62b5e290b
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https://doaj.org/article/6f2f436288994d16853156c62b5e290b

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