N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.

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Autores principales:	Hexin Shi, Lei Sun, Ying Wang, Aijie Liu, Xiaoming Zhan, Xiaohong Li, Miao Tang, Priscilla Anderton, Sara Hildebrand, Jiexia Quan, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f2f436288994d16853156c62b5e290b
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spelling	oai:doaj.org-article:6f2f436288994d16853156c62b5e290b2021-12-02T13:34:29ZN4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization10.1038/s41467-021-21711-52041-1723https://doaj.org/article/6f2f436288994d16853156c62b5e290b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21711-5https://doaj.org/toc/2041-1723NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.Hexin ShiLei SunYing WangAijie LiuXiaoming ZhanXiaohong LiMiao TangPriscilla AndertonSara HildebrandJiexia QuanSara LudwigEva Marie Y. MorescoBruce BeutlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hexin Shi Lei Sun Ying Wang Aijie Liu Xiaoming Zhan Xiaohong Li Miao Tang Priscilla Anderton Sara Hildebrand Jiexia Quan Sara Ludwig Eva Marie Y. Moresco Bruce Beutler N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
description	NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.
format	article
author	Hexin Shi Lei Sun Ying Wang Aijie Liu Xiaoming Zhan Xiaohong Li Miao Tang Priscilla Anderton Sara Hildebrand Jiexia Quan Sara Ludwig Eva Marie Y. Moresco Bruce Beutler
author_facet	Hexin Shi Lei Sun Ying Wang Aijie Liu Xiaoming Zhan Xiaohong Li Miao Tang Priscilla Anderton Sara Hildebrand Jiexia Quan Sara Ludwig Eva Marie Y. Moresco Bruce Beutler
author_sort	Hexin Shi
title	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_short	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_full	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_fullStr	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_full_unstemmed	N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
title_sort	n4bp1 negatively regulates nf-κb by binding and inhibiting nemo oligomerization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f2f436288994d16853156c62b5e290b
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N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

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