Targeting fidelity of adenine and cytosine base editors in mouse embryos

Understanding the risks of bystander and off-target editing is essential for genome engineering applications. Here, the authors analyze the fidelity of adenine and cytosine base editors in vivo.

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Autores principales:	Hye Kyung Lee, Michaela Willi, Shannon M. Miller, Sojung Kim, Chengyu Liu, David R. Liu, Lothar Hennighausen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f5a2eab54b647bf9d594d5cbd192da5
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spelling	oai:doaj.org-article:6f5a2eab54b647bf9d594d5cbd192da52021-12-02T16:49:51ZTargeting fidelity of adenine and cytosine base editors in mouse embryos10.1038/s41467-018-07322-72041-1723https://doaj.org/article/6f5a2eab54b647bf9d594d5cbd192da52018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07322-7https://doaj.org/toc/2041-1723Understanding the risks of bystander and off-target editing is essential for genome engineering applications. Here, the authors analyze the fidelity of adenine and cytosine base editors in vivo.Hye Kyung LeeMichaela WilliShannon M. MillerSojung KimChengyu LiuDavid R. LiuLothar HennighausenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hye Kyung Lee Michaela Willi Shannon M. Miller Sojung Kim Chengyu Liu David R. Liu Lothar Hennighausen Targeting fidelity of adenine and cytosine base editors in mouse embryos
description	Understanding the risks of bystander and off-target editing is essential for genome engineering applications. Here, the authors analyze the fidelity of adenine and cytosine base editors in vivo.
format	article
author	Hye Kyung Lee Michaela Willi Shannon M. Miller Sojung Kim Chengyu Liu David R. Liu Lothar Hennighausen
author_facet	Hye Kyung Lee Michaela Willi Shannon M. Miller Sojung Kim Chengyu Liu David R. Liu Lothar Hennighausen
author_sort	Hye Kyung Lee
title	Targeting fidelity of adenine and cytosine base editors in mouse embryos
title_short	Targeting fidelity of adenine and cytosine base editors in mouse embryos
title_full	Targeting fidelity of adenine and cytosine base editors in mouse embryos
title_fullStr	Targeting fidelity of adenine and cytosine base editors in mouse embryos
title_full_unstemmed	Targeting fidelity of adenine and cytosine base editors in mouse embryos
title_sort	targeting fidelity of adenine and cytosine base editors in mouse embryos
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6f5a2eab54b647bf9d594d5cbd192da5
work_keys_str_mv	AT hyekyunglee targetingfidelityofadenineandcytosinebaseeditorsinmouseembryos AT michaelawilli targetingfidelityofadenineandcytosinebaseeditorsinmouseembryos AT shannonmmiller targetingfidelityofadenineandcytosinebaseeditorsinmouseembryos AT sojungkim targetingfidelityofadenineandcytosinebaseeditorsinmouseembryos AT chengyuliu targetingfidelityofadenineandcytosinebaseeditorsinmouseembryos AT davidrliu targetingfidelityofadenineandcytosinebaseeditorsinmouseembryos AT lotharhennighausen targetingfidelityofadenineandcytosinebaseeditorsinmouseembryos
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Targeting fidelity of adenine and cytosine base editors in mouse embryos

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