Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controlling the integrity of tissue.

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Bibliographic Details
Main Authors: Christine-Maria Horejs, Jean-Philippe St-Pierre, Juha R. M. Ojala, Joseph A. M. Steele, Patricia Barros da Silva, Angela Rynne-Vidal, Stephanie A. Maynard, Catherine S. Hansel, Clara Rodríguez-Fernández, Manuel M. Mazo, Amanda Y. F. You, Alex J. Wang, Thomas von Erlach, Karl Tryggvason, Manuel López-Cabrera, Molly M. Stevens
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Q
Online Access:https://doaj.org/article/6f96d69568c34d5fb8957a8cd8f04a9a
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