MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.

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Autores principales: Huan Qiu, Bang-Ming Jin, Zhan-Feng Wang, Bin Xu, Qi-Fan Zheng, Li Zhang, Ling-Yu Zhu, Shuang Shi, Jun-Bo Yuan, Xiao Lin, Shu-Bin Gao, Guang-Hui Jin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6fb64604831e428da09697a05d822f59
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