MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.

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Autores principales:	Huan Qiu, Bang-Ming Jin, Zhan-Feng Wang, Bin Xu, Qi-Fan Zheng, Li Zhang, Ling-Yu Zhu, Shuang Shi, Jun-Bo Yuan, Xiao Lin, Shu-Bin Gao, Guang-Hui Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6fb64604831e428da09697a05d822f59
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spelling	oai:doaj.org-article:6fb64604831e428da09697a05d822f592021-12-02T14:42:15ZMEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response10.1038/s41467-020-14614-42041-1723https://doaj.org/article/6fb64604831e428da09697a05d822f592020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14614-4https://doaj.org/toc/2041-1723Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.Huan QiuBang-Ming JinZhan-Feng WangBin XuQi-Fan ZhengLi ZhangLing-Yu ZhuShuang ShiJun-Bo YuanXiao LinShu-Bin GaoGuang-Hui JinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Qiu Bang-Ming Jin Zhan-Feng Wang Bin Xu Qi-Fan Zheng Li Zhang Ling-Yu Zhu Shuang Shi Jun-Bo Yuan Xiao Lin Shu-Bin Gao Guang-Hui Jin MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
description	Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.
format	article
author	Huan Qiu Bang-Ming Jin Zhan-Feng Wang Bin Xu Qi-Fan Zheng Li Zhang Ling-Yu Zhu Shuang Shi Jun-Bo Yuan Xiao Lin Shu-Bin Gao Guang-Hui Jin
author_facet	Huan Qiu Bang-Ming Jin Zhan-Feng Wang Bin Xu Qi-Fan Zheng Li Zhang Ling-Yu Zhu Shuang Shi Jun-Bo Yuan Xiao Lin Shu-Bin Gao Guang-Hui Jin
author_sort	Huan Qiu
title	MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
title_short	MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
title_full	MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
title_fullStr	MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
title_full_unstemmed	MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
title_sort	men1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the dna damage response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6fb64604831e428da09697a05d822f59
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MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

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