NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.

Guardado en:
Detalles Bibliográficos
Autores principales: Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta, Domenica Caponio, Rojyar Khezri, Tyler G. Demarest, Yahyah Aman, David Figueroa, Marya Morevati, Ho-Joon Lee, Hisaya Kato, Henok Kassahun, Jong-Hyuk Lee, Deborah Filippelli, Mustafa Nazir Okur, Aswin Mangerich, Deborah L. Croteau, Yoshiro Maezawa, Costas A. Lyssiotis, Jun Tao, Koutaro Yokote, Tor Erik Rusten, Mark P. Mattson, Heinrich Jasper, Hilde Nilsen, Vilhelm A. Bohr
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/6fb6a8ffdc81475a8623958277a66533
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:6fb6a8ffdc81475a8623958277a66533
record_format dspace
spelling oai:doaj.org-article:6fb6a8ffdc81475a8623958277a665332021-12-02T16:57:29ZNAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome10.1038/s41467-019-13172-82041-1723https://doaj.org/article/6fb6a8ffdc81475a8623958277a665332019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13172-8https://doaj.org/toc/2041-1723The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.Evandro F. FangYujun HouSofie LautrupMartin Borch JensenBeimeng YangTanima SenGuptaDomenica CaponioRojyar KhezriTyler G. DemarestYahyah AmanDavid FigueroaMarya MorevatiHo-Joon LeeHisaya KatoHenok KassahunJong-Hyuk LeeDeborah FilippelliMustafa Nazir OkurAswin MangerichDeborah L. CroteauYoshiro MaezawaCostas A. LyssiotisJun TaoKoutaro YokoteTor Erik RustenMark P. MattsonHeinrich JasperHilde NilsenVilhelm A. BohrNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Evandro F. Fang
Yujun Hou
Sofie Lautrup
Martin Borch Jensen
Beimeng Yang
Tanima SenGupta
Domenica Caponio
Rojyar Khezri
Tyler G. Demarest
Yahyah Aman
David Figueroa
Marya Morevati
Ho-Joon Lee
Hisaya Kato
Henok Kassahun
Jong-Hyuk Lee
Deborah Filippelli
Mustafa Nazir Okur
Aswin Mangerich
Deborah L. Croteau
Yoshiro Maezawa
Costas A. Lyssiotis
Jun Tao
Koutaro Yokote
Tor Erik Rusten
Mark P. Mattson
Heinrich Jasper
Hilde Nilsen
Vilhelm A. Bohr
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
description The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.
format article
author Evandro F. Fang
Yujun Hou
Sofie Lautrup
Martin Borch Jensen
Beimeng Yang
Tanima SenGupta
Domenica Caponio
Rojyar Khezri
Tyler G. Demarest
Yahyah Aman
David Figueroa
Marya Morevati
Ho-Joon Lee
Hisaya Kato
Henok Kassahun
Jong-Hyuk Lee
Deborah Filippelli
Mustafa Nazir Okur
Aswin Mangerich
Deborah L. Croteau
Yoshiro Maezawa
Costas A. Lyssiotis
Jun Tao
Koutaro Yokote
Tor Erik Rusten
Mark P. Mattson
Heinrich Jasper
Hilde Nilsen
Vilhelm A. Bohr
author_facet Evandro F. Fang
Yujun Hou
Sofie Lautrup
Martin Borch Jensen
Beimeng Yang
Tanima SenGupta
Domenica Caponio
Rojyar Khezri
Tyler G. Demarest
Yahyah Aman
David Figueroa
Marya Morevati
Ho-Joon Lee
Hisaya Kato
Henok Kassahun
Jong-Hyuk Lee
Deborah Filippelli
Mustafa Nazir Okur
Aswin Mangerich
Deborah L. Croteau
Yoshiro Maezawa
Costas A. Lyssiotis
Jun Tao
Koutaro Yokote
Tor Erik Rusten
Mark P. Mattson
Heinrich Jasper
Hilde Nilsen
Vilhelm A. Bohr
author_sort Evandro F. Fang
title NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
title_short NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
title_full NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
title_fullStr NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
title_full_unstemmed NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
title_sort nad+ augmentation restores mitophagy and limits accelerated aging in werner syndrome
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/6fb6a8ffdc81475a8623958277a66533
work_keys_str_mv AT evandroffang nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT yujunhou nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT sofielautrup nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT martinborchjensen nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT beimengyang nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT tanimasengupta nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT domenicacaponio nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT rojyarkhezri nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT tylergdemarest nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT yahyahaman nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT davidfigueroa nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT maryamorevati nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT hojoonlee nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT hisayakato nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT henokkassahun nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT jonghyuklee nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT deborahfilippelli nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT mustafanazirokur nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT aswinmangerich nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT deborahlcroteau nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT yoshiromaezawa nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT costasalyssiotis nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT juntao nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT koutaroyokote nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT torerikrusten nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT markpmattson nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT heinrichjasper nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT hildenilsen nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
AT vilhelmabohr nadaugmentationrestoresmitophagyandlimitsacceleratedaginginwernersyndrome
_version_ 1718382571434278912

Ejemplares similares