A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

Using a CRISPR-based large-scale screen, Gilad et al. identify the genes that show synthetic lethality with an SRC-3 inhibitor in breast cancer cells while contrasting this with the estrogen receptor degrader fulvestrant. This study provides insights into the development of therapeutic strategies fo...

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Autores principales:	Yosi Gilad, Yossi Eliaz, Yang Yu, Adam M. Dean, San Jung Han, Li Qin, Bert W. O’Malley, David M. Lonard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6fce305479b5409cbdcf3ff5d35853b8
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spelling	oai:doaj.org-article:6fce305479b5409cbdcf3ff5d35853b82021-12-02T11:44:59ZA genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells10.1038/s42003-021-01929-12399-3642https://doaj.org/article/6fce305479b5409cbdcf3ff5d35853b82021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01929-1https://doaj.org/toc/2399-3642Using a CRISPR-based large-scale screen, Gilad et al. identify the genes that show synthetic lethality with an SRC-3 inhibitor in breast cancer cells while contrasting this with the estrogen receptor degrader fulvestrant. This study provides insights into the development of therapeutic strategies for cancer forms that involve SRC-3.Yosi GiladYossi EliazYang YuAdam M. DeanSan Jung HanLi QinBert W. O’MalleyDavid M. LonardNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yosi Gilad Yossi Eliaz Yang Yu Adam M. Dean San Jung Han Li Qin Bert W. O’Malley David M. Lonard A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
description	Using a CRISPR-based large-scale screen, Gilad et al. identify the genes that show synthetic lethality with an SRC-3 inhibitor in breast cancer cells while contrasting this with the estrogen receptor degrader fulvestrant. This study provides insights into the development of therapeutic strategies for cancer forms that involve SRC-3.
format	article
author	Yosi Gilad Yossi Eliaz Yang Yu Adam M. Dean San Jung Han Li Qin Bert W. O’Malley David M. Lonard
author_facet	Yosi Gilad Yossi Eliaz Yang Yu Adam M. Dean San Jung Han Li Qin Bert W. O’Malley David M. Lonard
author_sort	Yosi Gilad
title	A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
title_short	A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
title_full	A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
title_fullStr	A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
title_full_unstemmed	A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
title_sort	genome-scale crispr cas9 dropout screen identifies synthetically lethal targets in src-3 inhibited cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6fce305479b5409cbdcf3ff5d35853b8
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A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

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