Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats

Fruit peels, pericarps, or rinds are rich in phenolic/polyphenolic compounds with antioxidant properties and potentially beneficial effects against obesity and obesity-related non-communicable diseases. This study investigated the anti-obesity effects of matoa (<i>Pometia pinnata</i>) an...

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Autores principales:	Toshikazu Suzuki, Mayumi Nagata, Natsuko Kagawa, Shiori Takano, Nahrowi, Jun Nomura
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ApoB-48 Caco-2 cell monolayers hederagenin saponin hepatic lipid accumulation high-fat diet obesity Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/6fcece37c9594c1f9e178688af15312f
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spelling	oai:doaj.org-article:6fcece37c9594c1f9e178688af15312f2021-11-11T18:40:09ZAnti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats10.3390/molecules262167331420-3049https://doaj.org/article/6fcece37c9594c1f9e178688af15312f2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6733https://doaj.org/toc/1420-3049Fruit peels, pericarps, or rinds are rich in phenolic/polyphenolic compounds with antioxidant properties and potentially beneficial effects against obesity and obesity-related non-communicable diseases. This study investigated the anti-obesity effects of matoa (<i>Pometia pinnata</i>) and salak (<i>Salacca zalacca</i>) fruit peel. Neither matoa peel powder (MPP) nor salak peel powder (SPP) affected the body weight, visceral fat weight, or serum glucose or lipid levels of Sprague–Dawley rats when included as 1% (<i>w</i>/<i>w</i>) of a high-fat diet (HFD). However, MPP significantly decreased the hepatic lipid level. MPP at a dose of 3% (<i>w</i>/<i>w</i>) of the HFD decreased body weight, visceral fat, and serum triglyceride levels as well as the hepatic lipid content. The inhibitory effect of MPP on hepatic lipid accumulation was not enhanced when its concentration was increased from 1% to 3% of the HFD. The anti-obesity effect of matoa was partly explained by the inhibitory effect of the matoa peel extract on fatty acid-induced secretion of ApoB-48 protein, a marker of intestinal chylomicrons, in differentiated Caco-2 cell monolayers. We identified hederagenin saponins that are abundant in MPP as potential anti-obesity substances. These results will contribute towards the development of functional foods with anti-obesity effects using the matoa fruit peel.Toshikazu SuzukiMayumi NagataNatsuko KagawaShiori TakanoNahrowiJun NomuraMDPI AGarticleApoB-48Caco-2 cell monolayershederagenin saponinhepatic lipid accumulationhigh-fat dietobesityOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6733, p 6733 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ApoB-48 Caco-2 cell monolayers hederagenin saponin hepatic lipid accumulation high-fat diet obesity Organic chemistry QD241-441
spellingShingle	ApoB-48 Caco-2 cell monolayers hederagenin saponin hepatic lipid accumulation high-fat diet obesity Organic chemistry QD241-441 Toshikazu Suzuki Mayumi Nagata Natsuko Kagawa Shiori Takano Nahrowi Jun Nomura Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats
description	Fruit peels, pericarps, or rinds are rich in phenolic/polyphenolic compounds with antioxidant properties and potentially beneficial effects against obesity and obesity-related non-communicable diseases. This study investigated the anti-obesity effects of matoa (<i>Pometia pinnata</i>) and salak (<i>Salacca zalacca</i>) fruit peel. Neither matoa peel powder (MPP) nor salak peel powder (SPP) affected the body weight, visceral fat weight, or serum glucose or lipid levels of Sprague–Dawley rats when included as 1% (<i>w</i>/<i>w</i>) of a high-fat diet (HFD). However, MPP significantly decreased the hepatic lipid level. MPP at a dose of 3% (<i>w</i>/<i>w</i>) of the HFD decreased body weight, visceral fat, and serum triglyceride levels as well as the hepatic lipid content. The inhibitory effect of MPP on hepatic lipid accumulation was not enhanced when its concentration was increased from 1% to 3% of the HFD. The anti-obesity effect of matoa was partly explained by the inhibitory effect of the matoa peel extract on fatty acid-induced secretion of ApoB-48 protein, a marker of intestinal chylomicrons, in differentiated Caco-2 cell monolayers. We identified hederagenin saponins that are abundant in MPP as potential anti-obesity substances. These results will contribute towards the development of functional foods with anti-obesity effects using the matoa fruit peel.
format	article
author	Toshikazu Suzuki Mayumi Nagata Natsuko Kagawa Shiori Takano Nahrowi Jun Nomura
author_facet	Toshikazu Suzuki Mayumi Nagata Natsuko Kagawa Shiori Takano Nahrowi Jun Nomura
author_sort	Toshikazu Suzuki
title	Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats
title_short	Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats
title_full	Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats
title_fullStr	Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats
title_full_unstemmed	Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats
title_sort	anti-obesity effects of matoa (<i>pometia pinnata</i>) fruit peel powder in high-fat diet-fed rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6fcece37c9594c1f9e178688af15312f
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Anti-Obesity Effects of Matoa (<i>Pometia pinnata</i>) Fruit Peel Powder in High-Fat Diet-Fed Rats

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