Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteo...

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Main Authors: Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung-il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka, Taku Saito
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e0325
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https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e0325

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