Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteo...
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Nature Portfolio
2016
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oai:doaj.org-article:6fd2362e5f6846e1b0eafd3f836e03252021-12-02T17:32:22ZBiphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes10.1038/ncomms133362041-1723https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e03252016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13336https://doaj.org/toc/2041-1723Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression.Hiroshi KobayashiSong Ho ChangDaisuke MoriShozo ItohMakoto HirataYoko HosakaYuki TaniguchiKeita OkadaYoshifumi MoriFumiko YanoUng-il ChungHaruhiko AkiyamaHiroshi KawaguchiSakae TanakaTaku SaitoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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Science Q Hiroshi Kobayashi Song Ho Chang Daisuke Mori Shozo Itoh Makoto Hirata Yoko Hosaka Yuki Taniguchi Keita Okada Yoshifumi Mori Fumiko Yano Ung-il Chung Haruhiko Akiyama Hiroshi Kawaguchi Sakae Tanaka Taku Saito Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes |
description |
Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression. |
format |
article |
author |
Hiroshi Kobayashi Song Ho Chang Daisuke Mori Shozo Itoh Makoto Hirata Yoko Hosaka Yuki Taniguchi Keita Okada Yoshifumi Mori Fumiko Yano Ung-il Chung Haruhiko Akiyama Hiroshi Kawaguchi Sakae Tanaka Taku Saito |
author_facet |
Hiroshi Kobayashi Song Ho Chang Daisuke Mori Shozo Itoh Makoto Hirata Yoko Hosaka Yuki Taniguchi Keita Okada Yoshifumi Mori Fumiko Yano Ung-il Chung Haruhiko Akiyama Hiroshi Kawaguchi Sakae Tanaka Taku Saito |
author_sort |
Hiroshi Kobayashi |
title |
Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes |
title_short |
Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes |
title_full |
Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes |
title_fullStr |
Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes |
title_full_unstemmed |
Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes |
title_sort |
biphasic regulation of chondrocytes by rela through induction of anti-apoptotic and catabolic target genes |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e0325 |
work_keys_str_mv |
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