Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteo...

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Autores principales:	Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung-il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka, Taku Saito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e0325
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spelling	oai:doaj.org-article:6fd2362e5f6846e1b0eafd3f836e03252021-12-02T17:32:22ZBiphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes10.1038/ncomms133362041-1723https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e03252016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13336https://doaj.org/toc/2041-1723Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression.Hiroshi KobayashiSong Ho ChangDaisuke MoriShozo ItohMakoto HirataYoko HosakaYuki TaniguchiKeita OkadaYoshifumi MoriFumiko YanoUng-il ChungHaruhiko AkiyamaHiroshi KawaguchiSakae TanakaTaku SaitoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroshi Kobayashi Song Ho Chang Daisuke Mori Shozo Itoh Makoto Hirata Yoko Hosaka Yuki Taniguchi Keita Okada Yoshifumi Mori Fumiko Yano Ung-il Chung Haruhiko Akiyama Hiroshi Kawaguchi Sakae Tanaka Taku Saito Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
description	Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression.
format	article
author	Hiroshi Kobayashi Song Ho Chang Daisuke Mori Shozo Itoh Makoto Hirata Yoko Hosaka Yuki Taniguchi Keita Okada Yoshifumi Mori Fumiko Yano Ung-il Chung Haruhiko Akiyama Hiroshi Kawaguchi Sakae Tanaka Taku Saito
author_facet	Hiroshi Kobayashi Song Ho Chang Daisuke Mori Shozo Itoh Makoto Hirata Yoko Hosaka Yuki Taniguchi Keita Okada Yoshifumi Mori Fumiko Yano Ung-il Chung Haruhiko Akiyama Hiroshi Kawaguchi Sakae Tanaka Taku Saito
author_sort	Hiroshi Kobayashi
title	Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_short	Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_full	Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_fullStr	Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_full_unstemmed	Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_sort	biphasic regulation of chondrocytes by rela through induction of anti-apoptotic and catabolic target genes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e0325
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Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

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