Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteo...

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Autores principales: Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung-il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka, Taku Saito
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e0325
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spelling oai:doaj.org-article:6fd2362e5f6846e1b0eafd3f836e03252021-12-02T17:32:22ZBiphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes10.1038/ncomms133362041-1723https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e03252016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13336https://doaj.org/toc/2041-1723Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression.Hiroshi KobayashiSong Ho ChangDaisuke MoriShozo ItohMakoto HirataYoko HosakaYuki TaniguchiKeita OkadaYoshifumi MoriFumiko YanoUng-il ChungHaruhiko AkiyamaHiroshi KawaguchiSakae TanakaTaku SaitoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hiroshi Kobayashi
Song Ho Chang
Daisuke Mori
Shozo Itoh
Makoto Hirata
Yoko Hosaka
Yuki Taniguchi
Keita Okada
Yoshifumi Mori
Fumiko Yano
Ung-il Chung
Haruhiko Akiyama
Hiroshi Kawaguchi
Sakae Tanaka
Taku Saito
Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
description Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression.
format article
author Hiroshi Kobayashi
Song Ho Chang
Daisuke Mori
Shozo Itoh
Makoto Hirata
Yoko Hosaka
Yuki Taniguchi
Keita Okada
Yoshifumi Mori
Fumiko Yano
Ung-il Chung
Haruhiko Akiyama
Hiroshi Kawaguchi
Sakae Tanaka
Taku Saito
author_facet Hiroshi Kobayashi
Song Ho Chang
Daisuke Mori
Shozo Itoh
Makoto Hirata
Yoko Hosaka
Yuki Taniguchi
Keita Okada
Yoshifumi Mori
Fumiko Yano
Ung-il Chung
Haruhiko Akiyama
Hiroshi Kawaguchi
Sakae Tanaka
Taku Saito
author_sort Hiroshi Kobayashi
title Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_short Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_full Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_fullStr Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_full_unstemmed Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes
title_sort biphasic regulation of chondrocytes by rela through induction of anti-apoptotic and catabolic target genes
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6fd2362e5f6846e1b0eafd3f836e0325
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