Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq

Detection ofde novo, low frequency mutations is important for characterising heterogeneous cell populations, such as those found in cancer cell populations. Here the authors present o2n-seq, an ultrasensitive method with highly efficient data usage for detection of rare mutations.

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Autores principales:	Kaile Wang, Shujuan Lai, Xiaoxu Yang, Tianqi Zhu, Xuemei Lu, Chung-I Wu, Jue Ruan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6fd788ebdd2d4aa9a1ab98de73353467
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spelling	oai:doaj.org-article:6fd788ebdd2d4aa9a1ab98de733534672021-12-02T17:06:00ZUltrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq10.1038/ncomms153352041-1723https://doaj.org/article/6fd788ebdd2d4aa9a1ab98de733534672017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15335https://doaj.org/toc/2041-1723Detection ofde novo, low frequency mutations is important for characterising heterogeneous cell populations, such as those found in cancer cell populations. Here the authors present o2n-seq, an ultrasensitive method with highly efficient data usage for detection of rare mutations.Kaile WangShujuan LaiXiaoxu YangTianqi ZhuXuemei LuChung-I WuJue RuanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaile Wang Shujuan Lai Xiaoxu Yang Tianqi Zhu Xuemei Lu Chung-I Wu Jue Ruan Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq
description	Detection ofde novo, low frequency mutations is important for characterising heterogeneous cell populations, such as those found in cancer cell populations. Here the authors present o2n-seq, an ultrasensitive method with highly efficient data usage for detection of rare mutations.
format	article
author	Kaile Wang Shujuan Lai Xiaoxu Yang Tianqi Zhu Xuemei Lu Chung-I Wu Jue Ruan
author_facet	Kaile Wang Shujuan Lai Xiaoxu Yang Tianqi Zhu Xuemei Lu Chung-I Wu Jue Ruan
author_sort	Kaile Wang
title	Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq
title_short	Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq
title_full	Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq
title_fullStr	Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq
title_full_unstemmed	Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq
title_sort	ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6fd788ebdd2d4aa9a1ab98de73353467
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Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq

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