Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL

Abstract The pigment cell-specific protein PMEL forms a functional amyloid matrix in melanosomes onto which the pigment melanin is deposited. The amyloid core consists of a short proteolytic fragment, which we have termed the core-amyloid fragment (CAF) and perhaps additional parts of the protein, s...

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Autores principales: Susan M. Mitchell, Morven Graham, Xinran Liu, Ralf M. Leonhardt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6fe1f58f16b744199acb7c25c9e073c8
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