DNA methylation status correlates with adult β-cell regeneration capacity

Abstract The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood,...

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Autores principales: Ishant Khurana, Keith Al-Hasani, Scott Maxwell, Harikrishnan K.N., Jun Okabe, Mark E. Cooper, Patrick Collombat, Assam El-Osta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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R
Acceso en línea:https://doaj.org/article/7002e532a015471484dce7a5ddb7656f
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