DNA methylation status correlates with adult β-cell regeneration capacity

Abstract The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood,...

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Autores principales:	Ishant Khurana, Keith Al-Hasani, Scott Maxwell, Harikrishnan K.N., Jun Okabe, Mark E. Cooper, Patrick Collombat, Assam El-Osta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/7002e532a015471484dce7a5ddb7656f
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spelling	oai:doaj.org-article:7002e532a015471484dce7a5ddb7656f2021-12-02T14:18:14ZDNA methylation status correlates with adult β-cell regeneration capacity10.1038/s41536-021-00119-12057-3995https://doaj.org/article/7002e532a015471484dce7a5ddb7656f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00119-1https://doaj.org/toc/2057-3995Abstract The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.Ishant KhuranaKeith Al-HasaniScott MaxwellHarikrishnan K.N.Jun OkabeMark E. CooperPatrick CollombatAssam El-OstaNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Ishant Khurana Keith Al-Hasani Scott Maxwell Harikrishnan K.N. Jun Okabe Mark E. Cooper Patrick Collombat Assam El-Osta DNA methylation status correlates with adult β-cell regeneration capacity
description	Abstract The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.
format	article
author	Ishant Khurana Keith Al-Hasani Scott Maxwell Harikrishnan K.N. Jun Okabe Mark E. Cooper Patrick Collombat Assam El-Osta
author_facet	Ishant Khurana Keith Al-Hasani Scott Maxwell Harikrishnan K.N. Jun Okabe Mark E. Cooper Patrick Collombat Assam El-Osta
author_sort	Ishant Khurana
title	DNA methylation status correlates with adult β-cell regeneration capacity
title_short	DNA methylation status correlates with adult β-cell regeneration capacity
title_full	DNA methylation status correlates with adult β-cell regeneration capacity
title_fullStr	DNA methylation status correlates with adult β-cell regeneration capacity
title_full_unstemmed	DNA methylation status correlates with adult β-cell regeneration capacity
title_sort	dna methylation status correlates with adult β-cell regeneration capacity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7002e532a015471484dce7a5ddb7656f
work_keys_str_mv	AT ishantkhurana dnamethylationstatuscorrelateswithadultbcellregenerationcapacity AT keithalhasani dnamethylationstatuscorrelateswithadultbcellregenerationcapacity AT scottmaxwell dnamethylationstatuscorrelateswithadultbcellregenerationcapacity AT harikrishnankn dnamethylationstatuscorrelateswithadultbcellregenerationcapacity AT junokabe dnamethylationstatuscorrelateswithadultbcellregenerationcapacity AT markecooper dnamethylationstatuscorrelateswithadultbcellregenerationcapacity AT patrickcollombat dnamethylationstatuscorrelateswithadultbcellregenerationcapacity AT assamelosta dnamethylationstatuscorrelateswithadultbcellregenerationcapacity
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DNA methylation status correlates with adult β-cell regeneration capacity

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