Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Phthalidyl esters, commonly used prodrug moieties, are mostly prepared as a racemate. Here, the authors report an N-heterocylcic carbene-catalysed enantioselective acetalization of carboxylic acids and dialdehydes to give phthalidyl esters in high yields with good enantioselectivity.

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Bibliographic Details
Main Authors: Yingguo Liu, Qiao Chen, Chengli Mou, Lutai Pan, Xiaoyong Duan, Xingkuan Chen, Hongzhong Chen, Yanli Zhao, Yunpeng Lu, Zhichao Jin, Yonggui Robin Chi
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/700c8b89ebfe4c5e8bec995b25860645
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Internet

https://doaj.org/article/700c8b89ebfe4c5e8bec995b25860645

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