Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Phthalidyl esters, commonly used prodrug moieties, are mostly prepared as a racemate. Here, the authors report an N-heterocylcic carbene-catalysed enantioselective acetalization of carboxylic acids and dialdehydes to give phthalidyl esters in high yields with good enantioselectivity.

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Autores principales:	Yingguo Liu, Qiao Chen, Chengli Mou, Lutai Pan, Xiaoyong Duan, Xingkuan Chen, Hongzhong Chen, Yanli Zhao, Yunpeng Lu, Zhichao Jin, Yonggui Robin Chi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/700c8b89ebfe4c5e8bec995b25860645
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spelling	oai:doaj.org-article:700c8b89ebfe4c5e8bec995b258606452021-12-02T16:57:40ZCatalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs10.1038/s41467-019-09445-x2041-1723https://doaj.org/article/700c8b89ebfe4c5e8bec995b258606452019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09445-xhttps://doaj.org/toc/2041-1723Phthalidyl esters, commonly used prodrug moieties, are mostly prepared as a racemate. Here, the authors report an N-heterocylcic carbene-catalysed enantioselective acetalization of carboxylic acids and dialdehydes to give phthalidyl esters in high yields with good enantioselectivity.Yingguo LiuQiao ChenChengli MouLutai PanXiaoyong DuanXingkuan ChenHongzhong ChenYanli ZhaoYunpeng LuZhichao JinYonggui Robin ChiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingguo Liu Qiao Chen Chengli Mou Lutai Pan Xiaoyong Duan Xingkuan Chen Hongzhong Chen Yanli Zhao Yunpeng Lu Zhichao Jin Yonggui Robin Chi Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
description	Phthalidyl esters, commonly used prodrug moieties, are mostly prepared as a racemate. Here, the authors report an N-heterocylcic carbene-catalysed enantioselective acetalization of carboxylic acids and dialdehydes to give phthalidyl esters in high yields with good enantioselectivity.
format	article
author	Yingguo Liu Qiao Chen Chengli Mou Lutai Pan Xiaoyong Duan Xingkuan Chen Hongzhong Chen Yanli Zhao Yunpeng Lu Zhichao Jin Yonggui Robin Chi
author_facet	Yingguo Liu Qiao Chen Chengli Mou Lutai Pan Xiaoyong Duan Xingkuan Chen Hongzhong Chen Yanli Zhao Yunpeng Lu Zhichao Jin Yonggui Robin Chi
author_sort	Yingguo Liu
title	Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
title_short	Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
title_full	Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
title_fullStr	Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
title_full_unstemmed	Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
title_sort	catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/700c8b89ebfe4c5e8bec995b25860645
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Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

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