Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Phthalidyl esters, commonly used prodrug moieties, are mostly prepared as a racemate. Here, the authors report an N-heterocylcic carbene-catalysed enantioselective acetalization of carboxylic acids and dialdehydes to give phthalidyl esters in high yields with good enantioselectivity.

Guardado en:
Detalles Bibliográficos
Autores principales: Yingguo Liu, Qiao Chen, Chengli Mou, Lutai Pan, Xiaoyong Duan, Xingkuan Chen, Hongzhong Chen, Yanli Zhao, Yunpeng Lu, Zhichao Jin, Yonggui Robin Chi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/700c8b89ebfe4c5e8bec995b25860645
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares