Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA

The pH dependence of the activity of Escherichia colimain sodium-proton antiporter NhaA is still not fully understood. Here, the authors use continuous constant pH molecular dynamics simulations to identify NhaA proton carrier residues and elucidate its gating and ion transport processes.

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Autores principales: Yandong Huang, Wei Chen, David L. Dotson, Oliver Beckstein, Jana Shen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/70117e4c9a03499c8e50e36bf805717b
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