Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA

The pH dependence of the activity of Escherichia colimain sodium-proton antiporter NhaA is still not fully understood. Here, the authors use continuous constant pH molecular dynamics simulations to identify NhaA proton carrier residues and elucidate its gating and ion transport processes.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yandong Huang, Wei Chen, David L. Dotson, Oliver Beckstein, Jana Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70117e4c9a03499c8e50e36bf805717b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70117e4c9a03499c8e50e36bf805717b
record_format	dspace
spelling	oai:doaj.org-article:70117e4c9a03499c8e50e36bf805717b2021-12-02T17:32:05ZMechanism of pH-dependent activation of the sodium-proton antiporter NhaA10.1038/ncomms129402041-1723https://doaj.org/article/70117e4c9a03499c8e50e36bf805717b2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12940https://doaj.org/toc/2041-1723The pH dependence of the activity of Escherichia colimain sodium-proton antiporter NhaA is still not fully understood. Here, the authors use continuous constant pH molecular dynamics simulations to identify NhaA proton carrier residues and elucidate its gating and ion transport processes.Yandong HuangWei ChenDavid L. DotsonOliver BecksteinJana ShenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yandong Huang Wei Chen David L. Dotson Oliver Beckstein Jana Shen Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA
description	The pH dependence of the activity of Escherichia colimain sodium-proton antiporter NhaA is still not fully understood. Here, the authors use continuous constant pH molecular dynamics simulations to identify NhaA proton carrier residues and elucidate its gating and ion transport processes.
format	article
author	Yandong Huang Wei Chen David L. Dotson Oliver Beckstein Jana Shen
author_facet	Yandong Huang Wei Chen David L. Dotson Oliver Beckstein Jana Shen
author_sort	Yandong Huang
title	Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA
title_short	Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA
title_full	Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA
title_fullStr	Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA
title_full_unstemmed	Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA
title_sort	mechanism of ph-dependent activation of the sodium-proton antiporter nhaa
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/70117e4c9a03499c8e50e36bf805717b
work_keys_str_mv	AT yandonghuang mechanismofphdependentactivationofthesodiumprotonantiporternhaa AT weichen mechanismofphdependentactivationofthesodiumprotonantiporternhaa AT davidldotson mechanismofphdependentactivationofthesodiumprotonantiporternhaa AT oliverbeckstein mechanismofphdependentactivationofthesodiumprotonantiporternhaa AT janashen mechanismofphdependentactivationofthesodiumprotonantiporternhaa
_version_	1718380374902439936

Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA

Ejemplares similares