Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative

Reducing aerobic ethanol production, a phenomenon referred to as the Crabtree effect, may open up new perspectives for using yeast as a cell factory. Here, the authors turn the Crabtree-positive yeast into Crabtree negative by combined engineering of cytosolic acetyl-CoA metabolism and mutating the...

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Autores principales: Zongjie Dai, Mingtao Huang, Yun Chen, Verena Siewers, Jens Nielsen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7016397e466f4d609b444d494707624d
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