Role of cholesterol in substrate recognition by $$\gamma$$ γ -secretase

Abstract $$\gamma$$ γ -Secretase is an enzyme known to cleave multiple substrates within their transmembrane domains, with the amyloid precursor protein of Alzheimer’s Disease among the most prominent examples. The activity of $$\gamma$$ γ -secretase strictly depends on the membrane cholesterol cont...

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Autores principales: Łukasz Nierzwicki, Michał Olewniczak, Paweł Chodnicki, Jacek Czub
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/701eb6d37c8f4ff68a4a16bbb5458b11
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