Widespread signatures of natural selection across human complex traits and functional genomic categories

Methods to study how natural selection shapes genetic architecture of complex traits rely on individual level genome-wide association study (GWAS) data. Here, the authors present a Bayesian method using GWAS summary statistics to study genetic architecture and apply this to 155 complex traits.

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Detalles Bibliográficos
Autores principales:	Jian Zeng, Angli Xue, Longda Jiang, Luke R. Lloyd-Jones, Yang Wu, Huanwei Wang, Zhili Zheng, Loic Yengo, Kathryn E. Kemper, Michael E. Goddard, Naomi R. Wray, Peter M. Visscher, Jian Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7021cd9e0b7a461ab740f757fc19b112
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spelling	oai:doaj.org-article:7021cd9e0b7a461ab740f757fc19b1122021-12-02T12:11:27ZWidespread signatures of natural selection across human complex traits and functional genomic categories10.1038/s41467-021-21446-32041-1723https://doaj.org/article/7021cd9e0b7a461ab740f757fc19b1122021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21446-3https://doaj.org/toc/2041-1723Methods to study how natural selection shapes genetic architecture of complex traits rely on individual level genome-wide association study (GWAS) data. Here, the authors present a Bayesian method using GWAS summary statistics to study genetic architecture and apply this to 155 complex traits.Jian ZengAngli XueLongda JiangLuke R. Lloyd-JonesYang WuHuanwei WangZhili ZhengLoic YengoKathryn E. KemperMichael E. GoddardNaomi R. WrayPeter M. VisscherJian YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Zeng Angli Xue Longda Jiang Luke R. Lloyd-Jones Yang Wu Huanwei Wang Zhili Zheng Loic Yengo Kathryn E. Kemper Michael E. Goddard Naomi R. Wray Peter M. Visscher Jian Yang Widespread signatures of natural selection across human complex traits and functional genomic categories
description	Methods to study how natural selection shapes genetic architecture of complex traits rely on individual level genome-wide association study (GWAS) data. Here, the authors present a Bayesian method using GWAS summary statistics to study genetic architecture and apply this to 155 complex traits.
format	article
author	Jian Zeng Angli Xue Longda Jiang Luke R. Lloyd-Jones Yang Wu Huanwei Wang Zhili Zheng Loic Yengo Kathryn E. Kemper Michael E. Goddard Naomi R. Wray Peter M. Visscher Jian Yang
author_facet	Jian Zeng Angli Xue Longda Jiang Luke R. Lloyd-Jones Yang Wu Huanwei Wang Zhili Zheng Loic Yengo Kathryn E. Kemper Michael E. Goddard Naomi R. Wray Peter M. Visscher Jian Yang
author_sort	Jian Zeng
title	Widespread signatures of natural selection across human complex traits and functional genomic categories
title_short	Widespread signatures of natural selection across human complex traits and functional genomic categories
title_full	Widespread signatures of natural selection across human complex traits and functional genomic categories
title_fullStr	Widespread signatures of natural selection across human complex traits and functional genomic categories
title_full_unstemmed	Widespread signatures of natural selection across human complex traits and functional genomic categories
title_sort	widespread signatures of natural selection across human complex traits and functional genomic categories
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7021cd9e0b7a461ab740f757fc19b112
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Widespread signatures of natural selection across human complex traits and functional genomic categories

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