Widespread signatures of natural selection across human complex traits and functional genomic categories

Methods to study how natural selection shapes genetic architecture of complex traits rely on individual level genome-wide association study (GWAS) data. Here, the authors present a Bayesian method using GWAS summary statistics to study genetic architecture and apply this to 155 complex traits.

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Detalles Bibliográficos
Autores principales: Jian Zeng, Angli Xue, Longda Jiang, Luke R. Lloyd-Jones, Yang Wu, Huanwei Wang, Zhili Zheng, Loic Yengo, Kathryn E. Kemper, Michael E. Goddard, Naomi R. Wray, Peter M. Visscher, Jian Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7021cd9e0b7a461ab740f757fc19b112
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