Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice

Chronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility in preclinical models of alcohol use disorder.

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Autores principales:	Yann Ehinger, Ziyang Zhang, Khanhky Phamluong, Drishti Soneja, Kevan M. Shokat, Dorit Ron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7072a98d7a1d453daff66668b3c58af7
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spelling	oai:doaj.org-article:7072a98d7a1d453daff66668b3c58af72021-12-02T16:14:24ZBrain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice10.1038/s41467-021-24567-x2041-1723https://doaj.org/article/7072a98d7a1d453daff66668b3c58af72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24567-xhttps://doaj.org/toc/2041-1723Chronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility in preclinical models of alcohol use disorder.Yann EhingerZiyang ZhangKhanhky PhamluongDrishti SonejaKevan M. ShokatDorit RonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yann Ehinger Ziyang Zhang Khanhky Phamluong Drishti Soneja Kevan M. Shokat Dorit Ron Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
description	Chronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility in preclinical models of alcohol use disorder.
format	article
author	Yann Ehinger Ziyang Zhang Khanhky Phamluong Drishti Soneja Kevan M. Shokat Dorit Ron
author_facet	Yann Ehinger Ziyang Zhang Khanhky Phamluong Drishti Soneja Kevan M. Shokat Dorit Ron
author_sort	Yann Ehinger
title	Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
title_short	Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
title_full	Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
title_fullStr	Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
title_full_unstemmed	Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
title_sort	brain-specific inhibition of mtorc1 eliminates side effects resulting from mtorc1 blockade in the periphery and reduces alcohol intake in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7072a98d7a1d453daff66668b3c58af7
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Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice

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