Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice

por Yann Ehinger, Ziyang Zhang, Khanhky Phamluong, Drishti Soneja, Kevan M. Shokat, Dorit Ron
Publicado 2021

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

por Morris E Feldman, Beth Apsel, Aino Uotila, Robbie Loewith, Zachary A Knight, Davide Ruggero, Kevan M Shokat
Publicado 2009

Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

por Pedro Beltrao, Jonathan C Trinidad, Dorothea Fiedler, Assen Roguev, Wendell A Lim, Kevan M Shokat, Alma L Burlingame, Nevan J Krogan
Publicado 2009

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.

por Lara Wohlbold, Karl A Merrick, Saurav De, Ramon Amat, Jun Hyun Kim, Stéphane Larochelle, Jasmina J Allen, Chao Zhang, Kevan M Shokat, John H J Petrini, Robert P Fisher
Publicado 2012

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

por Mark E Burkard, John Maciejowski, Verónica Rodriguez-Bravo, Michael Repka, Drew M Lowery, Karl R Clauser, Chao Zhang, Kevan M Shokat, Steven A Carr, Michael B Yaffe, Prasad V Jallepalli
Publicado 2009