BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

par Fred C. Lam, Yi Wen Kong, Qiuying Huang, Tu-Lan Vu Han, Amanda D. Maffa, Ekkehard M. Kasper, Michael B. Yaffe
Publié 2020

Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division

par Joon Ho Kang, Georgios Katsikis, Zhaoqi Li, Kiera M. Sapp, Max A. Stockslager, Daniel Lim, Matthew G. Vander Heiden, Michael B. Yaffe, Scott R. Manalis, Teemu P. Miettinen
Publié 2020

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

par Fred C. Lam, Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael B Yaffe, Scott R Floyd, Paula T Hammond
Publié 2018

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

par Mark E Burkard, John Maciejowski, Verónica Rodriguez-Bravo, Michael Repka, Drew M Lowery, Karl R Clauser, Chao Zhang, Kevan M Shokat, Steven A Carr, Michael B Yaffe, Prasad V Jallepalli
Publié 2009

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

par Jun-Ha Hwang, A Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh, Sung A Moon, Mi Ran Byun, Hana Jeong, Hyo Kyung Kim, Michael B. Yaffe, Eun Sook Hwang, Jeong-Ho Hong
Publié 2019

Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

par Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, Michael B. Yaffe
Publié 2020

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

par Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe
Publié 2010

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

par Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke, Patricia Ho, Elizabeth M. Gonzalez, Graham Buchan, Kenin Qian, Gabrielle Gionet, Emily Girard, Margo Coxon, Matthew G. Rees, Lisa Brenan, Frank Dubois, Ofer Shapira, Noah F. Greenwald, Melanie Pages, Amanda Balboni Iniguez, Brenton R. Paolella, Alice Meng, Claire Sinai, Giovanni Roti, Neekesh V. Dharia, Amanda Creech, Benjamin Tanenbaum, Prasidda Khadka, Adam Tracy, Hong L. Tiv, Andrew L. Hong, Shannon Coy, Rumana Rashid, Jia-Ren Lin, Glenn S. Cowley, Fred C. Lam, Amy Goodale, Yenarae Lee, Kathleen Schoolcraft, Francisca Vazquez, William C. Hahn, Aviad Tsherniak, James E. Bradner, Michael B. Yaffe, Till Milde, Stefan M. Pfister, Jun Qi, Monica Schenone, Steven A. Carr, Keith L. Ligon, Mark W. Kieran, Sandro Santagata, James M. Olson, Prafulla C. Gokhale, Jacob D. Jaffe, David E. Root, Kimberly Stegmaier, Cory M. Johannessen, Rameen Beroukhim
Publié 2019