A canthin-6-one derivative induces cell death by apoptosis/necroptosis-like with DNA damage in acute myeloid cells

A canthin-6-one derivative induces cell death by apoptosis/necroptosis-like with DNA damage in acute myeloid cells

Natural products have long been considered a relevant source of new antitumor agents. Despite advances in the treatment of younger patients with acute myeloid leukemia (AML), the prognosis of elderly patients remains poor, with a high frequency of relapse. The cytotoxicity of canthin-6-one alkaloids...

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Autores principales: Heron F.V. Torquato, Manoel Trindade Rodrigues Junior, Cauê Santos Lima, Roberto Theodoro de Araujo Júnior, Fernanda Talhati, Dhebora Albuquerque Dias, Giselle Zenker Justo, Alice Teixeira Ferreira, Ronaldo Aloise Pilli, Edgar J. Paredes-Gamero
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
Alkaloids
Canthin-6-one
Cell death
Apoptosis
Necroptosis
DNA damage
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/70bf41681ed4460881a6f8a53c9217f0
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https://doaj.org/article/70bf41681ed4460881a6f8a53c9217f0

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