DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.

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Bibliographic Details
Main Authors:	Roland Beckmann, Kristian Jensen, Sebastian Fenn, Janina Speck, Katrin Krause, Anastasia Meier, Melanie Röth, Sascha Fauser, Raymond Kimbung, Derek T. Logan, Martin Steegmaier, Hubert Kettenberger
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b
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spelling	oai:doaj.org-article:70c0f8f5eaae4c48be3ad457ee0a7a4b2021-12-02T13:57:44ZDutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously10.1038/s41467-021-20949-32041-1723https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20949-3https://doaj.org/toc/2041-1723Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.Roland BeckmannKristian JensenSebastian FennJanina SpeckKatrin KrauseAnastasia MeierMelanie RöthSascha FauserRaymond KimbungDerek T. LoganMartin SteegmaierHubert KettenbergerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roland Beckmann Kristian Jensen Sebastian Fenn Janina Speck Katrin Krause Anastasia Meier Melanie Röth Sascha Fauser Raymond Kimbung Derek T. Logan Martin Steegmaier Hubert Kettenberger DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
description	Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.
format	article
author	Roland Beckmann Kristian Jensen Sebastian Fenn Janina Speck Katrin Krause Anastasia Meier Melanie Röth Sascha Fauser Raymond Kimbung Derek T. Logan Martin Steegmaier Hubert Kettenberger
author_facet	Roland Beckmann Kristian Jensen Sebastian Fenn Janina Speck Katrin Krause Anastasia Meier Melanie Röth Sascha Fauser Raymond Kimbung Derek T. Logan Martin Steegmaier Hubert Kettenberger
author_sort	Roland Beckmann
title	DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_short	DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_full	DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_fullStr	DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_full_unstemmed	DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_sort	dutafabs are engineered therapeutic fab fragments that can bind two targets simultaneously
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b
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DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

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