Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response
The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation with single-cell proteomic phenotypes characterized by mass cytometry.
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Nature Portfolio
2021
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oai:doaj.org-article:70db0dc523da4d5ab06795129ce345592021-12-02T13:26:41ZLandscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response10.1038/s41467-021-22303-z2041-1723https://doaj.org/article/70db0dc523da4d5ab06795129ce345592021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22303-zhttps://doaj.org/toc/2041-1723The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation with single-cell proteomic phenotypes characterized by mass cytometry.Dimitra GeorgopoulouMaurizio CallariOscar M. RuedaAbigail SheaAlistair MartinAgnese GiovannettiFatime QosajAli DariushSuet-Feung ChinLarissa S. CarnevalliElena ProvenzanoWendy GreenwoodGiulia LerdaElham EsmaeilishirazifardMartin O’ReillyVioleta SerraDario BressanIMAXT ConsortiumGordon B. MillsH. Raza AliSabina S. CosulichGregory J. HannonAlejandra BrunaCarlos CaldasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dimitra Georgopoulou Maurizio Callari Oscar M. Rueda Abigail Shea Alistair Martin Agnese Giovannetti Fatime Qosaj Ali Dariush Suet-Feung Chin Larissa S. Carnevalli Elena Provenzano Wendy Greenwood Giulia Lerda Elham Esmaeilishirazifard Martin O’Reilly Violeta Serra Dario Bressan IMAXT Consortium Gordon B. Mills H. Raza Ali Sabina S. Cosulich Gregory J. Hannon Alejandra Bruna Carlos Caldas Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response |
| description |
The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation with single-cell proteomic phenotypes characterized by mass cytometry. |
| format |
article |
| author |
Dimitra Georgopoulou Maurizio Callari Oscar M. Rueda Abigail Shea Alistair Martin Agnese Giovannetti Fatime Qosaj Ali Dariush Suet-Feung Chin Larissa S. Carnevalli Elena Provenzano Wendy Greenwood Giulia Lerda Elham Esmaeilishirazifard Martin O’Reilly Violeta Serra Dario Bressan IMAXT Consortium Gordon B. Mills H. Raza Ali Sabina S. Cosulich Gregory J. Hannon Alejandra Bruna Carlos Caldas |
| author_facet |
Dimitra Georgopoulou Maurizio Callari Oscar M. Rueda Abigail Shea Alistair Martin Agnese Giovannetti Fatime Qosaj Ali Dariush Suet-Feung Chin Larissa S. Carnevalli Elena Provenzano Wendy Greenwood Giulia Lerda Elham Esmaeilishirazifard Martin O’Reilly Violeta Serra Dario Bressan IMAXT Consortium Gordon B. Mills H. Raza Ali Sabina S. Cosulich Gregory J. Hannon Alejandra Bruna Carlos Caldas |
| author_sort |
Dimitra Georgopoulou |
| title |
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response |
| title_short |
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response |
| title_full |
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response |
| title_fullStr |
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response |
| title_full_unstemmed |
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response |
| title_sort |
landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/70db0dc523da4d5ab06795129ce34559 |
| work_keys_str_mv |
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| _version_ |
1718393036740755456 |