Origin Replication Complex Binding, Nucleosome Depletion Patterns, and a Primary Sequence Motif Can Predict Origins of Replication in a Genome with Epigenetic Centromeres

Origin Replication Complex Binding, Nucleosome Depletion Patterns, and a Primary Sequence Motif Can Predict Origins of Replication in a Genome with Epigenetic Centromeres

ABSTRACT Origins of DNA replication are key genetic elements, yet their identification remains elusive in most organisms. In previous work, we found that centromeres contain origins of replication (ORIs) that are determined epigenetically in the pathogenic yeast Candida albicans. In this study, we u...

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Bibliographic Details
Main Authors: Hung-Ji Tsai, Joshua A. Baller, Ivan Liachko, Amnon Koren, Laura S. Burrack, Meleah A. Hickman, Mathuravani A. Thevandavakkam, Laura N. Rusche, Judith Berman
Format: article
Language:EN
Published: American Society for Microbiology 2014
Subjects:
Microbiology
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Online Access:https://doaj.org/article/70e68d4e98f34ef9b64f1dcf46320fb4
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