The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease.

<h4>Background</h4>Cyclooxygenase-2 (COX-2) is a key enzyme involved in the conversion of arachidonic acid into prostaglandins. COX-2 is mainly induced at sites of inflammation in response to proinflammatory cytokines such as interleukin-1α/β, interferon-γ and tumor necrosis factor-α pro...

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Autores principales: Hilbert S de Vries, Rene H M te Morsche, Martijn G H van Oijen, Iris D Nagtegaal, Wilbert H M Peters, Dirk J de Jong
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/70f4f6a05b2f4637b3efa9d081aae634
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