Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase.

Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity-onset diabetes of the young type II (MODY-II) and persistent hypogl...

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Autores principales: Mioara Larion, Roberto Kopke Salinas, Lei Bruschweiler-Li, Brian G Miller, Rafael Brüschweiler
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/7100dd73a44140ac85fbfb0580fc0fd5
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