TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells

TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells

Abstract CRISPR/Cas9 mediated gene editing of patient-derived hematopoietic stem and progenitor cells (HSPCs) ex vivo followed by autologous transplantation of the edited HSPCs back to the patient can provide a potential cure for monogenic blood disorders such as β-hemoglobinopathies. One challenge...

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Detalles Bibliográficos
Autores principales: Jonathan Yen, Michael Fiorino, Yi Liu, Steve Paula, Scott Clarkson, Lisa Quinn, William R. Tschantz, Heath Klock, Ning Guo, Carsten Russ, Vionnie W. C. Yu, Craig Mickanin, Susan C. Stevenson, Cameron Lee, Yi Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Hematopoietic Stem And Progenitor Cells (HSPCs)
Purified Cas9 Protein
HSPC Expansion
Neon Electroporation
Syringe Connector
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7126e75f7f804ba7a87cf87864786123
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https://doaj.org/article/7126e75f7f804ba7a87cf87864786123

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