Host gene constraints and genomic context impact the expression and evolution of human microRNAs

Recent miRNAs tend to emerge within coding genes. Here, by analysing miRNA expression data from six species and comparing genomes from 13 species, the authors report that host genes may provide stronger expression constraints to intragenic miRNAs in the long run.

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Bibliographic Details
Main Authors:	Gustavo S. França, Maria D. Vibranovski, Pedro A. F. Galante
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/714ff1a3aa5b4560b77772ee7d229898
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spelling	oai:doaj.org-article:714ff1a3aa5b4560b77772ee7d2298982021-12-02T15:34:54ZHost gene constraints and genomic context impact the expression and evolution of human microRNAs10.1038/ncomms114382041-1723https://doaj.org/article/714ff1a3aa5b4560b77772ee7d2298982016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11438https://doaj.org/toc/2041-1723Recent miRNAs tend to emerge within coding genes. Here, by analysing miRNA expression data from six species and comparing genomes from 13 species, the authors report that host genes may provide stronger expression constraints to intragenic miRNAs in the long run.Gustavo S. FrançaMaria D. VibranovskiPedro A. F. GalanteNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gustavo S. França Maria D. Vibranovski Pedro A. F. Galante Host gene constraints and genomic context impact the expression and evolution of human microRNAs
description	Recent miRNAs tend to emerge within coding genes. Here, by analysing miRNA expression data from six species and comparing genomes from 13 species, the authors report that host genes may provide stronger expression constraints to intragenic miRNAs in the long run.
format	article
author	Gustavo S. França Maria D. Vibranovski Pedro A. F. Galante
author_facet	Gustavo S. França Maria D. Vibranovski Pedro A. F. Galante
author_sort	Gustavo S. França
title	Host gene constraints and genomic context impact the expression and evolution of human microRNAs
title_short	Host gene constraints and genomic context impact the expression and evolution of human microRNAs
title_full	Host gene constraints and genomic context impact the expression and evolution of human microRNAs
title_fullStr	Host gene constraints and genomic context impact the expression and evolution of human microRNAs
title_full_unstemmed	Host gene constraints and genomic context impact the expression and evolution of human microRNAs
title_sort	host gene constraints and genomic context impact the expression and evolution of human micrornas
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/714ff1a3aa5b4560b77772ee7d229898
work_keys_str_mv	AT gustavosfranca hostgeneconstraintsandgenomiccontextimpacttheexpressionandevolutionofhumanmicrornas AT mariadvibranovski hostgeneconstraintsandgenomiccontextimpacttheexpressionandevolutionofhumanmicrornas AT pedroafgalante hostgeneconstraintsandgenomiccontextimpacttheexpressionandevolutionofhumanmicrornas
_version_	1718386724700160000

Host gene constraints and genomic context impact the expression and evolution of human microRNAs

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