Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry

Data-independent acquisition (DIA)-based proteomics often relies on mass spectrum libraries from data-dependent acquisition experiments. Here, the authors present a method to generate DIA-based chromatogram libraries, enabling DIA-only workflows and detecting more peptides than with spectrum librari...

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Autores principales: Brian C. Searle, Lindsay K. Pino, Jarrett D. Egertson, Ying S. Ting, Robert T. Lawrence, Brendan X. MacLean, Judit Villén, Michael J. MacCoss
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/71667bdd5c6f47bf95aa8da07df2ca8c
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