Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death

Many forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin infla...

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Auteurs principaux:	Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/716b05e17f3c43fa880e9ce7ddca92ca
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id	oai:doaj.org-article:716b05e17f3c43fa880e9ce7ddca92ca
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spelling	oai:doaj.org-article:716b05e17f3c43fa880e9ce7ddca92ca2021-12-02T15:35:48ZModulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death10.1038/s41467-019-11858-72041-1723https://doaj.org/article/716b05e17f3c43fa880e9ce7ddca92ca2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11858-7https://doaj.org/toc/2041-1723Many forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin inflammation similar to cpdm mice with genetic deletion of Sharpin.Katsuhiro SasakiAi HimenoTomoko NakagawaYoshiteru SasakiHiroshi KiyonariKazuhiro IwaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katsuhiro Sasaki Ai Himeno Tomoko Nakagawa Yoshiteru Sasaki Hiroshi Kiyonari Kazuhiro Iwai Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
description	Many forms of autoimmune disorder involve abnormal T cell functions, but how this versatility is achieved is not fully clear. Here the authors show that Sharpin-deficient Treg cells induce the death of local keratinocytes via multiple programmed cell death and innate inflammation to cause skin inflammation similar to cpdm mice with genetic deletion of Sharpin.
format	article
author	Katsuhiro Sasaki Ai Himeno Tomoko Nakagawa Yoshiteru Sasaki Hiroshi Kiyonari Kazuhiro Iwai
author_facet	Katsuhiro Sasaki Ai Himeno Tomoko Nakagawa Yoshiteru Sasaki Hiroshi Kiyonari Kazuhiro Iwai
author_sort	Katsuhiro Sasaki
title	Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_short	Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_full	Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_fullStr	Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_full_unstemmed	Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
title_sort	modulation of autoimmune pathogenesis by t cell-triggered inflammatory cell death
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/716b05e17f3c43fa880e9ce7ddca92ca
work_keys_str_mv	AT katsuhirosasaki modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath AT aihimeno modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath AT tomokonakagawa modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath AT yoshiterusasaki modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath AT hiroshikiyonari modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath AT kazuhiroiwai modulationofautoimmunepathogenesisbytcelltriggeredinflammatorycelldeath
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Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death

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