Thermodynamics of the DNA damage repair steps of human 8-oxoguanine DNA glycosylase.

Human 8-oxoguanine DNA glycosylase (hOGG1) is a key enzyme responsible for initiating the base excision repair of 7,8-dihydro-8-oxoguanosine (oxoG). In this study a thermodynamic analysis of the interaction of hOGG1 with specific and non-specific DNA-substrates is performed based on stopped-flow kin...

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Autores principales: Nikita A Kuznetsov, Alexandra A Kuznetsova, Yuri N Vorobjev, Lev N Krasnoperov, Olga S Fedorova
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/71729f17fa0346cdaddce31af0d648aa
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