HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects.

HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects.

Celiac disease (CD) is a chronic inflammatory disorder triggered after gluten ingestion in genetically susceptible individuals. The major genetic determinants are HLA-DQA1*05 and HLA-DQB1*02, which encode the DQ2 heterodimer. These alleles are commonly inherited in cis with DRB1*03∶01, which is asso...

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Main Authors: Luz María Medrano, Bárbara Dema, Arturo López-Larios, Carlos Maluenda, Andrés Bodas, Natalia López-Palacios, M Ángeles Figueredo, Miguel Fernández-Arquero, Concepción Núñez
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/718a5ea391c042a9b26e7d3d7dcb427e
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