Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression

Abstract The inhibitory effects of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) modulates T-cell depletion. T-cell depletion is one of the key mechanisms of hepatitis B virus (HBV) persistence, in particular liver disease progression and the development of hepatocellular carci...

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Autores principales:	Nghiem Xuan Hoan, Pham Thi Minh Huyen, Mai Thanh Binh, Ngo Tat Trung, Dao Phuong Giang, Bui Thuy Linh, Dang Thi Ngoc Dung, Srinivas Reddy Pallerla, Peter G. Kremsner, Thirumalaisamy P. Velavan, Mai Hong Bang, Le Huu Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71be686ae0ba4298b28c563a77522a3e
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spelling	oai:doaj.org-article:71be686ae0ba4298b28c563a77522a3e2021-12-02T14:15:53ZGenetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression10.1038/s41598-021-87537-92045-2322https://doaj.org/article/71be686ae0ba4298b28c563a77522a3e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87537-9https://doaj.org/toc/2045-2322Abstract The inhibitory effects of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) modulates T-cell depletion. T-cell depletion is one of the key mechanisms of hepatitis B virus (HBV) persistence, in particular liver disease progression and the development of hepatocellular carcinoma (HCC). This case–control study aimed to understand the significance of PD-1 polymorphisms (PD-1.5 and PD-1.9) association with HBV infection risk and HBV-induced liver disease progression. Genotyping of PD-1.5 and PD-1.9 variants was performed by direct Sanger sequencing in 682 HBV-infected patients including chronic hepatitis (CHB, n = 193), liver cirrhosis (LC, n = 183), hepatocellular carcinoma (HCC, n = 306) and 283 healthy controls (HC). To analyze the association of PD-1 variants with liver disease progression, a binary logistic regression, adjusted for age and gender, was performed using different genetic models. The PD-1.9 T allele and PD-1.9 TT genotype are significantly associated with increased risk of LC, HCC, and LC + HCC. The frequencies of PD-1.5 TT genotype and PD-1.5 T allele are significantly higher in HCC compared to LC patients. The haplotype CT (PD-1.5 C and PD-1.9 T) was significantly associated with increased risk of LC, HCC, and LC + HCC. In addition, the TC (PD-1.5 T and PD-1.9 C) haplotype was associated with the risk of HCC compared to non-HCC. The PD-1.5 CC, PD-1.9 TT, genotype, and the CC (PD-1.5 C and PD-1.9) haplotype are associated with unfavorable laboratory parameters in chronic hepatitis B patients. PD-1.5 and PD1.9 are useful prognostic predictors for HBV infection risk and liver disease progression.Nghiem Xuan HoanPham Thi Minh HuyenMai Thanh BinhNgo Tat TrungDao Phuong GiangBui Thuy LinhDang Thi Ngoc DungSrinivas Reddy PallerlaPeter G. KremsnerThirumalaisamy P. VelavanMai Hong BangLe Huu SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nghiem Xuan Hoan Pham Thi Minh Huyen Mai Thanh Binh Ngo Tat Trung Dao Phuong Giang Bui Thuy Linh Dang Thi Ngoc Dung Srinivas Reddy Pallerla Peter G. Kremsner Thirumalaisamy P. Velavan Mai Hong Bang Le Huu Song Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
description	Abstract The inhibitory effects of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) modulates T-cell depletion. T-cell depletion is one of the key mechanisms of hepatitis B virus (HBV) persistence, in particular liver disease progression and the development of hepatocellular carcinoma (HCC). This case–control study aimed to understand the significance of PD-1 polymorphisms (PD-1.5 and PD-1.9) association with HBV infection risk and HBV-induced liver disease progression. Genotyping of PD-1.5 and PD-1.9 variants was performed by direct Sanger sequencing in 682 HBV-infected patients including chronic hepatitis (CHB, n = 193), liver cirrhosis (LC, n = 183), hepatocellular carcinoma (HCC, n = 306) and 283 healthy controls (HC). To analyze the association of PD-1 variants with liver disease progression, a binary logistic regression, adjusted for age and gender, was performed using different genetic models. The PD-1.9 T allele and PD-1.9 TT genotype are significantly associated with increased risk of LC, HCC, and LC + HCC. The frequencies of PD-1.5 TT genotype and PD-1.5 T allele are significantly higher in HCC compared to LC patients. The haplotype CT (PD-1.5 C and PD-1.9 T) was significantly associated with increased risk of LC, HCC, and LC + HCC. In addition, the TC (PD-1.5 T and PD-1.9 C) haplotype was associated with the risk of HCC compared to non-HCC. The PD-1.5 CC, PD-1.9 TT, genotype, and the CC (PD-1.5 C and PD-1.9) haplotype are associated with unfavorable laboratory parameters in chronic hepatitis B patients. PD-1.5 and PD1.9 are useful prognostic predictors for HBV infection risk and liver disease progression.
format	article
author	Nghiem Xuan Hoan Pham Thi Minh Huyen Mai Thanh Binh Ngo Tat Trung Dao Phuong Giang Bui Thuy Linh Dang Thi Ngoc Dung Srinivas Reddy Pallerla Peter G. Kremsner Thirumalaisamy P. Velavan Mai Hong Bang Le Huu Song
author_facet	Nghiem Xuan Hoan Pham Thi Minh Huyen Mai Thanh Binh Ngo Tat Trung Dao Phuong Giang Bui Thuy Linh Dang Thi Ngoc Dung Srinivas Reddy Pallerla Peter G. Kremsner Thirumalaisamy P. Velavan Mai Hong Bang Le Huu Song
author_sort	Nghiem Xuan Hoan
title	Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
title_short	Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
title_full	Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
title_fullStr	Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
title_full_unstemmed	Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression
title_sort	genetic variants of programmed cell death 1 are associated with hbv infection and liver disease progression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/71be686ae0ba4298b28c563a77522a3e
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Genetic variants of programmed cell death 1 are associated with HBV infection and liver disease progression

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